171590 β-Amyloid Peptide (1-40, Gln¹¹), Human

171590
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      β-Amyloid protein has both neurotrophic and neurotoxic effects depending upon the neuronal age and concentration of β-protein. A major component of senile and Alzheimer’s plaques. Promotes the down-regulation of Bcl-2 and enhances the phosphorylation of Tau protein.
      Catalogue Number171590
      Brand Family Calbiochem®
      References
      ReferencesChauhan, A., et al. 1998. J. Neurol. Sci. 154, 159.
      Aksenov, M.Y., et al. 1996. J. Neurochem. 66, 2050.
      Naiki, H., and Nakakuki, K. 1996. Lab Invest. 74, 374.
      Paradis, E., et al. 1996. J. Neurosci. 16, 7533.
      Terzi, E., et al. 1995. J. Mol. Biol. 252, 633.
      Askenov, M.Y., et al. 1995. J. Neurochem. 65, 1899.
      Klegeris, A., et al. 1994. Biochem. Biophys. Res. Commun. 199, 984.
      Kowalska, M.A., and Badellino, K. 1994. Biochem. Biophys. Res. Commun. 205, 1829.
      Yankner, B.A., et al. 1990. Science 250, 279.
      Product Information
      CAS number131438-79-4
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₉₄H₂₉₆N₅₄O₅₇S
      Chemical formulaC₁₉₄H₂₉₆N₅₄O₅₇S
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceH-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at-20°C. Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      171590

      References

      Reference overview
      Chauhan, A., et al. 1998. J. Neurol. Sci. 154, 159.
      Aksenov, M.Y., et al. 1996. J. Neurochem. 66, 2050.
      Naiki, H., and Nakakuki, K. 1996. Lab Invest. 74, 374.
      Paradis, E., et al. 1996. J. Neurosci. 16, 7533.
      Terzi, E., et al. 1995. J. Mol. Biol. 252, 633.
      Askenov, M.Y., et al. 1995. J. Neurochem. 65, 1899.
      Klegeris, A., et al. 1994. Biochem. Biophys. Res. Commun. 199, 984.
      Kowalska, M.A., and Badellino, K. 1994. Biochem. Biophys. Res. Commun. 205, 1829.
      Yankner, B.A., et al. 1990. Science 250, 279.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      Descriptionβ-Amyloid Peptide (Aβ) is the main constituent in both senile plaques and diffuse deposits in Alzheimer's diseased brains. Under appropriate conditions the soluble amyloid peptides aggregate into the fibrils associated with the disease state. It has been proposed that Aβ peptide may increase the sensitivity of neurons to oxidative damage by downregulating bcl-2 and/or inactivating glutamine synthetase.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number131438-79-4
      Chemical formulaC₁₉₄H₂₉₆N₅₄O₅₇S
      Peptide SequenceH-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Gln-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
      Purity≥95% by HPLC
      Solubility5% Acetic acid (2 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at-20°C. Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesChauhan, A., et al. 1998. J. Neurol. Sci. 154, 159.
      Aksenov, M.Y., et al. 1996. J. Neurochem. 66, 2050.
      Naiki, H., and Nakakuki, K. 1996. Lab Invest. 74, 374.
      Paradis, E., et al. 1996. J. Neurosci. 16, 7533.
      Terzi, E., et al. 1995. J. Mol. Biol. 252, 633.
      Askenov, M.Y., et al. 1995. J. Neurochem. 65, 1899.
      Klegeris, A., et al. 1994. Biochem. Biophys. Res. Commun. 199, 984.
      Kowalska, M.A., and Badellino, K. 1994. Biochem. Biophys. Res. Commun. 205, 1829.
      Yankner, B.A., et al. 1990. Science 250, 279.