194348 3ʹ-Azido-3ʹ-deoxythymidine

194348
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₁₃N₅O₄ 30516-87-1
      Description
      Overview

      This product has been discontinued.





      Inhibitor of HIV-1 reverse transcriptase that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. Enters CNS by diffusion and causes irreversible telomere shortening.
      Catalogue Number194348
      Brand Family Calbiochem®
      SynonymsAZT
      References
      ReferencesGomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107.
      Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223.
      Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211.
      Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
      Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.
      Product Information
      CAS number30516-87-1
      FormWhite crystalline
      Hill FormulaC₁₀H₁₃N₅O₄
      Chemical formulaC₁₀H₁₃N₅O₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity>99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXP2072000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      3ʹ-Azido-3ʹ-deoxythymidine MSDS

      Title

      Safety Data Sheet (SDS) 

      3ʹ-Azido-3ʹ-deoxythymidine Certificates of Analysis

      TitleLot Number
      194348

      References

      Reference overview
      Gomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107.
      Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223.
      Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211.
      Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
      Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Nucleotides and Bases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsAZT
      DescriptionInhibitor of HIV-1 reverse transcriptase that blocks the incorporation of nucleotides into growing DNA strands. Useful for anti-viral and anti-cancer studies. Enters CNS by diffusion. Causes irreversible telomere shortening.
      FormWhite crystalline
      CAS number30516-87-1
      RTECSXP2072000
      Chemical formulaC₁₀H₁₃N₅O₄
      Structure formulaStructure formula
      Purity>99% by HPLC
      SolubilityH₂O (20 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 10123
      ReferencesGomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107.
      Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223.
      Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211.
      Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
      Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.