100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

100105
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₉H₃₇N₃O₆ 52665-69-7

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      100105-10MG
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          Plastic ampoule 10 mg
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          100105-1MG
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              100105-50MG
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                  100105-5MG
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                      Description
                      OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
                      Catalogue Number100105
                      Brand Family Calbiochem®
                      SynonymsCalcimycin
                      References
                      ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
                      Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
                      Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
                      Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
                      Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
                      Product Information
                      CAS number52665-69-7
                      ATP CompetitiveN
                      FormWhite solid
                      Hill FormulaC₂₉H₃₇N₃O₆
                      Chemical formulaC₂₉H₃₇N₃O₆
                      ReversibleN
                      Structure formula ImageStructure formula Image
                      Applications
                      Biological Information
                      Primary TargetMitochondrial ATPase
                      Purity≥98% by TLC
                      Physicochemical Information
                      Cell permeableN
                      Dimensions
                      Materials Information
                      Toxicological Information
                      Safety Information according to GHS
                      RTECSDM4676000
                      Safety Information
                      Product Usage Statements
                      Storage and Shipping Information
                      Ship Code Ambient Temperature Only
                      Toxicity Standard Handling
                      Storage +2°C to +8°C
                      Protect from Light Protect from light
                      Do not freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
                      Packaging Information
                      Transport Information
                      Supplemental Information
                      Specifications

                      Documentation

                      MSDS

                      Title

                      Safety Data Sheet (SDS) 

                      Certificates of Analysis

                      TitleLot Number
                      100105

                      References

                      Reference overview
                      Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
                      Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
                      Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
                      Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
                      Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

                      Brochure

                      Title
                      Calcium Metabolism and Related Products Brochure
                      Caspases and other Apoptosis Related Tools Brochure
                      Ionophores Technical Bulletin
                      Nitric Oxide and Oxidative Stress Brochure
                      Tools and Tips for Analyzing Apoptosis
                      Data Sheet

                      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                      Revision07-April-2008 RFH
                      SynonymsCalcimycin
                      DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
                      FormWhite solid
                      CAS number52665-69-7
                      RTECSDM4676000
                      Chemical formulaC₂₉H₃₇N₃O₆
                      Structure formulaStructure formula
                      Purity≥98% by TLC
                      SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
                      Storage +2°C to +8°C
                      Protect from light
                      Do Not Freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
                      Toxicity Standard Handling
                      Merck USA index14, 1639
                      ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
                      Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
                      Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
                      Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
                      Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

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                      Categories

                      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores