124028 Akt Inhibitor XI - Calbiochem

124028
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₁H₉Cl₂CuN₃O₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 µM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.

      Catalogue Number124028
      Brand Family Calbiochem®
      Synonyms3-Formylchromone thiosemicarbazone, Cu(II)Cl₂ Complex, FPA-124
      References
      ReferencesBarve, V., et al. 2006. J. Med. Chem. 49, 3800.
      Product Information
      ATP CompetitiveN
      FormGreen solid
      Hill FormulaC₁₁H₉Cl₂CuN₃O₂S
      Chemical formulaC₁₁H₉Cl₂CuN₃O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>100 nM against Akt
      Purity≥98% by Elemental Analysis
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor XI - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Akt Inhibitor XI - Calbiochem Certificates of Analysis

      TitleLot Number
      124028

      References

      Reference overview
      Barve, V., et al. 2006. J. Med. Chem. 49, 3800.

      Brochure

      Title
      Akt
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      Synonyms3-Formylchromone thiosemicarbazone, Cu(II)Cl₂ Complex, FPA-124
      DescriptionA cell-permeable copper complex (Cu2+/Cu+ redox couple in the range of +0.28 to +0.35 V) that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity (IC50 = 100 nM). Inhibits tumor growth both in cultured cells in vitro (IC50 ranges from 10 to 34 µM) and in mice in vivo (25 mg/kg, iv) without any apparent adverse effect to the animals.
      FormGreen solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₁H₉Cl₂CuN₃O₂S
      Structure formulaStructure formula
      Purity≥98% by Elemental Analysis
      SolubilityH₂O (5 mg/ml) or DMSO (2 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesBarve, V., et al. 2006. J. Med. Chem. 49, 3800.