128135 Aloisine, RP106

128135
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₁₉N₃O 496864-15-4
      Description
      Overview

      This product has been discontinued.





      A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3 (IC50 = 700 nM, 1.5 µM, and 920 nM, respectively).
      Catalogue Number128135
      Brand Family Calbiochem®
      SynonymsRP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
      References
      ReferencesMettey, Y., et al. 2003. J. Med. Chem. 46, 222.
      Product Information
      CAS number496864-15-4
      ATP CompetitiveY
      FormCream-colored solid
      Hill FormulaC₁₇H₁₉N₃O
      Chemical formulaC₁₇H₁₉N₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCdkl1, Cdkl5, GSK-3
      Primary Target IC<sub>50</sub>700 nM, 1.5 µM, 920 µM against Cdkl1, Cdkl5, GSK-3, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      128135

      References

      Reference overview
      Mettey, Y., et al. 2003. J. Med. Chem. 46, 222.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 RFH
      SynonymsRP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
      DescriptionA cell-permeable, pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 700 nM), Cdk5/p25 (IC50 = 1.5 µM), and GSK-3 (IC50 = 920 nM).
      FormCream-colored solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number496864-15-4
      Chemical formulaC₁₇H₁₉N₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or MeOH (200 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMettey, Y., et al. 2003. J. Med. Chem. 46, 222.