182300 Aristolochic Acid

182300
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₁₁NO₇ 313-67-7
      Description
      Overview

      This product has been discontinued.





      A 1:1 mixture of aristolochic acids I and II. Phenanthrenecarboxylic acid derivative found in Aristolochiaceae that has been reported to inhibit phospholipase A2 (PLA2) from various snake venoms as well as human platelet and synovial fluid PLA2. Inhibits ionophore-stimulated PLA2 activity (IC50 = 40 µM) in human neutrophils. Exhibits greater inhibitory activity towards group II PLA2 than group I PLA2.
      Catalogue Number182300
      Brand Family Calbiochem®
      References
      ReferencesLindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
      Rosenthal, M.D., et al. 1992. Biochim. Biophys. Acta 1126, 319.
      Winkler, J.D., et al. 1992. Biochem. Pharmacol. 44, 2055.
      Kopp, R., and Pfeiffer, A. 1990. Cancer Res. 50, 6490.
      Product Information
      CAS number313-67-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₇H₁₁NO₇
      Chemical formulaC₁₇H₁₁NO₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetionophore-stimulated PLA 2 activity
      Primary Target IC<sub>50</sub>40 µM inhibiting ionophore-stimulated PLA2 activity in human neutrophils
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCF3325000
      Safety Information
      R PhraseR: 23/24/25-40

      Toxic by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      182300

      References

      Reference overview
      Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
      Rosenthal, M.D., et al. 1992. Biochim. Biophys. Acta 1126, 319.
      Winkler, J.D., et al. 1992. Biochem. Pharmacol. 44, 2055.
      Kopp, R., and Pfeiffer, A. 1990. Cancer Res. 50, 6490.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-October-2009 JSW
      DescriptionA 1:1 mixture of aristolochic acids I and II. Phenanthrenecarboxylic acid derivative occurring in Aristolochiaceae that has been reported to inhibit phospholipase A2 (PLA2) from various snake venoms as well as human platelet and synovial fluid PLA2. Also inhibits ionophore-stimulated PLA2 activity (IC50 = 40 µM) and Ca2+-dependent arachidonic acid released in human neutrophils. Exhibits greater inhibitory activity towards group II PLA2 versus group I PLA2.
      FormYellow solid
      CAS number313-67-7
      RTECSCF3325000
      Chemical formulaC₁₇H₁₁NO₇
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 786
      ReferencesLindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
      Rosenthal, M.D., et al. 1992. Biochim. Biophys. Acta 1126, 319.
      Winkler, J.D., et al. 1992. Biochem. Pharmacol. 44, 2055.
      Kopp, R., and Pfeiffer, A. 1990. Cancer Res. 50, 6490.