05-23-2401 Calcitonin, Salmon

05-23-2401
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      Overview

      Replacement Information

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      05-23-2401-25MG
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      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
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          Will advise
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          Plastic ampoule 25 mg
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          Description
          OverviewSynthetic, salmon calcitonin. A 32 amino acid residue peptide that is shown to stimulate bone formation and inhibit bone resorption. Has ability to cross mucous membranes. Has no significant effect on inositol phosphate accumulation.
          Catalogue Number05-23-2401
          Brand Family Calbiochem®
          References
          ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
          Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
          MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
          Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
          Product Information
          CAS number47931-85-1
          FormLyophilized
          FormulationSold on the basis of peptide content.
          Hill FormulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
          Chemical formulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
          Hygroscopic Hygroscopic
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Peptide ContentY
          Peptide SequenceH-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEV8000000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          05-23-2401

          References

          Reference overview
          Gennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
          Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
          MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
          Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-September-2008 RFH
          DescriptionSynthetic, salmon calcitonin. Calcitonin is a single-chain peptide hormone of 32 amino acid residues with a disulfide bridge between cysteines 1 and 7. It is produced in the parafollicular C cells of the thyroid gland and acts to stimulate bone formation by osteoblasts and inhibits bone resorption. Part of the effect of calcitonin appears to be mediated through increasing cAMP concentrations in osteoclasts. Has ability to cross mucus membranes. Has no significant effect on inositol phosphate accumulation.
          FormLyophilized
          FormulationSold on the basis of peptide content.
          CAS number47931-85-1
          RTECSEV8000000
          Chemical formulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
          Peptide SequenceH-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)
          Purity≥98% by HPLC
          Solubility5% Acetic acid (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 1643
          ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
          Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
          MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
          Chambers, T.J., et al. 1985. J. Pathol. 145, 297.