420345 | Kaempferol - CAS 520-18-3 - Calbiochem

420345
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      Overview

      Key Spec Table

      Empirical Formula CAS #

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      420345-25MG
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          25 mg
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          Description
          Overview A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM).
          Catalogue Number
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          Synonyms 3,4ʹ,5,7-Tetrahydroxyflavone
          References
          References Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
          Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
          Wang, H., et al. 2000. Phytomedicine 7, 15.
          Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
          Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
          Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
          Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
          Product Information
          CAS number
          ATP Competitive
          Form Yellow solid
          Hill Formula
          Chemical formula
          Molar Mass 286.2
          Reversible
          Structure formula Image
          Applications
          Biological Information
          Primary Target Topoisomerase I-catalyzed DNA religation in HL-60 cells
          Primary Target IC50 180 µM against COX-1 activity
          Purity ≥97% by HPLC
          Physicochemical Information
          Cell permeable
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS
          Safety Information
          R Phrase R: 36/37/38-40

          Irritating to eyes, respiratory system and skin.
          Limited evidence of a carcinogenic effect.
          S Phrase S: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
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          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
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          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          420345

          References

          Reference overview
          Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
          Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
          Wang, H., et al. 2000. Phytomedicine 7, 15.
          Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
          Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
          Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
          Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 02-January-2008 JSW
          Synonyms 3,4ʹ,5,7-Tetrahydroxyflavone
          Description A cell-permeable, phytoestrogen that offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50 = 180 µM) and COX-2 (IC50 = ~15 µM).
          Form Yellow solid
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          CAS number
          RTECS
          Molar mass 286.2
          Chemical formula
          Structure formula
          Purity ≥97% by HPLC
          Solubility DMSO (25 mg/ml) or Ethanol (20 mg/ml)
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          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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          Merck USA index
          References Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
          Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
          Wang, H., et al. 2000. Phytomedicine 7, 15.
          Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
          Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
          Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
          Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.