119150 Adenosine A2A Receptor Antagonist II, SCH-58261 - CAS 160098-96-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261

119150
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      Overview

      Replacement Information

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      119150-10MG
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          		 Glass bottle 10 mg
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          Description
          OverviewA highly potent and selective antagonist of adenosine A2A receptor (Ki = 600 pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287 nM; 5.0 µM, and > 10 µM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats.
          Catalogue Number119150
          Brand Family Calbiochem®
          Synonyms2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261
          References
          ReferencesOngini, E., et al. 1999. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7.
          Monopoli, A., et al. 1998. Neuroport. 9, 3955.
          Zocchi, C., et al. 1996. J. Pharmacol. Exp. Ther. 276, 398.
          Popoli, P., et al. 2000. Neuropsychopharmacology. 22, 522.
          Product Information
          CAS number160098-96-4
          FormOff-white solid
          Hill FormulaC₁₈H₁₅N₇O
          Chemical formulaC₁₈H₁₅N₇O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA2A Receptor
          Primary Target K<sub>i</sub>600 pM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          119150

          References

          Reference overview
          Ongini, E., et al. 1999. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7.
          Monopoli, A., et al. 1998. Neuroport. 9, 3955.
          Zocchi, C., et al. 1996. J. Pharmacol. Exp. Ther. 276, 398.
          Popoli, P., et al. 2000. Neuropsychopharmacology. 22, 522.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-May-2013 JSW
          Synonyms2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261
          DescriptionA highly potent and selective antagonist of adenosine A2A receptor (Ki = 600 pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287 nM; 5.0 µM, and > 10 µM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number160098-96-4
          Chemical formulaC₁₈H₁₅N₇O
          Structure formulaStructure formula
          Purity≥99% by HPLC
          Solubility100 mM in DMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesOngini, E., et al. 1999. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7.
          Monopoli, A., et al. 1998. Neuroport. 9, 3955.
          Zocchi, C., et al. 1996. J. Pharmacol. Exp. Ther. 276, 398.
          Popoli, P., et al. 2000. Neuropsychopharmacology. 22, 522.