155100 Aminogenistein

155100
  
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      Overview

      Replacement Information
      Description
      OverviewInhibits protein-tyrosine kinase activity of p56lck (IC50 = 1.2 µM).
      Catalogue Number155100
      Brand Family Calbiochem®
      Synonyms4ʹ-Amino-6-hydroxyflavone
      References
      ReferencesCushman, M., et al. 1991. J. Med. Chem. 34, 798.
      Product Information
      CAS number132018-32-7
      FormSolid
      Hill FormulaC₁₅H₁₁NO₃
      Chemical formulaC₁₅H₁₁NO₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetp56lck
      Primary Target IC<sub>50</sub>1.2 µM
      Purity>95% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      155100

      References

      Reference overview
      Cushman, M., et al. 1991. J. Med. Chem. 34, 798.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms4ʹ-Amino-6-hydroxyflavone
      DescriptionInhibits protein-tyrosine kinase activity of p56lck (IC50 = 1.2 µM). p56lck is a 56 kDa enzyme that exhibits considerable sequence homology to pp60src and other members of the src family of tyrosine kinases. The expression of p56lck is normally restricted to lymphoid cells, primarily those of the T cell lineage. p56lck is thought to play a role in mediating signal transduction via the CD4 receptor during lymphocyte activation. The presence of a 4'-amino and a 6-hydroxyl group on 4'-amino-6-hydroxyflavone promotes high affinity interactions with p56lck, decreasing p56lck interactions with protein-serine/threonine kinases.
      FormSolid
      CAS number132018-32-7
      Chemical formulaC₁₅H₁₁NO₃
      Structure formulaStructure formula
      Purity>95% by NMR
      SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesCushman, M., et al. 1991. J. Med. Chem. 34, 798.