176700 Angiostatin® Protein, Human

176700
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We are offering Angiostatin K1-3, Human, Recombinant, P. pastoris (Cat. No. 176708) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






      A proteolytic fragment of plasminogen constituting kringles 1 - 4. A specific inhibitor of endothelial cell proliferation and one of the most potent and specific natural inhibitors of angiogenesis and metastatic tumor growth. Human angiostatin significantly inhibits bFGF-induced endothelial cell proliferation and migration at concentrations ranging from 300 nM - 1.0 µM.
      Catalogue Number176700
      Brand Family Calbiochem®
      References
      ReferencesCao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O’Reilly, M.S., et al. 1994. Cell 79, 315.
      Product Information
      CAS number86090-08-6
      DeclarationSold under license of U.S. Patent 6,024,688 and corresponding patents.
      FormLyophilized
      FormulationLyophilized from 40 mM NaCl, 20 mM HEPES-NaOH, pH 8.0.
      Applications
      Biological Information
      Purity≥98% by SDS-PAGE (migrates as a doublet)
      SourcePrepared from fluid that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      Contaminantsplasmin, plasminogen: none detected
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSBW2140000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage DEEP FREEZE (-70°C)
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      176700

      References

      Reference overview
      Cao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O’Reilly, M.S., et al. 1994. Cell 79, 315.