171537 Anti-Amyloid Precursor Protein Mouse mAb (3E9)

171537
  
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      Overview

      Replacement Information

      Key Spec Table

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      Description
      Overview

      This product has been discontinued.





      Recognizes the ~110-135 kDa amyloid precursor protein (APP695).
    • Antibody Target Gene Symbol: APP
    • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
    • Entrez Gene Name: amyloid beta (A4) precursor protein
    • Hu Entrez ID: 351 (Related Antibodies: 171610, PC729,PC152, PC151, PC150, PC149,NE1012, 171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598)
    • Mu Entrez ID: 11820
    • Rat Entrez ID: 54226
    • Catalogue Number171537
      Brand Family Calbiochem®
      References
      Product Information
      FormLyophilized
      FormulationLyophilized from PBS, 1% sucrose.
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Paraffin Sections
      Application NotesImmunoblotting (5-10 µg/ml)
      Paraffin Sections (5-10 µg/ml, see comments)
      Application CommentsThis antibody may not detect APP in normal brain tissue, or APP in samples from later-stage Alzheimer's brain tissue. Suitable for formalin fixed paraffin sections. Variables associated with assay conditions will dictate the proper working dilutions.
      Biological Information
      Immunogena synthetic peptide (LEVPTDGNAGLLAEPQIAMFC) corresponding to amino acids 18-38 of human amyloid precursor protein (APP₆₉₅)
      ImmunogenHuman
      Clone3E9
      HostMouse
      IsotypeIgG₁
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsReconstitute with dH₂O. Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      171537

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2007 RFH
      ApplicationImmunoblotting (5-10 µg/ml)
      Paraffin Sections (5-10 µg/ml, see comments)
      DescriptionMouse monoclonal antibody purified by ammonium sulfate precipitation and protein A chromatography. Recognizes the ~110-135 kDa amyloid precursor (APP) protein.
      BackgroundAmyloid β protein (or A4) is the major protein subunit of amyloid fibrils and deposits characteristic of the neurodegenerative disorder Alzheimer's disease. The 4.5 kDa A4 protein is derived from proteolytic cleavage of amyloid precursor protein (APP). Three types of APPs (APP695, APP751, APP770), derived from mRNAs generated by alternatively spliced transcripts, are reported. The primary structure of APP695 (the 695 residue polypeptide) indicates that it is a glycosylated protein that spans the membrane once and has a large extracellular domain and a small cytoplasmic domain. The A4 protein, comprised of residues 597-638 of APP695, includes 28 residues from the extracellular domain and 14-15 residues from the transmembrane domain. This monoclonal anti-APP antibody is specific for human APP.
      HostMouse
      Immunogen speciesHuman
      Immunogena synthetic peptide (LEVPTDGNAGLLAEPQIAMFC) corresponding to amino acids 18-38 of human amyloid precursor protein (APP₆₉₅)
      Clone3E9
      IsotypeIgG₁
      Specieshuman
      FormLyophilized
      FormulationLyophilized from PBS, 1% sucrose.
      Preservative≤0.1% sodium azide
      CommentsThis antibody may not detect APP in normal brain tissue, or APP in samples from later-stage Alzheimer's brain tissue. Suitable for formalin fixed paraffin sections. Variables associated with assay conditions will dictate the proper working dilutions.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsReconstitute with dH₂O. Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling