169756 Antithrombin III, Human Plasma - CAS 90170-80-2 - Calbiochem

Antithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATIII, Heparin cofactor, Factor Xa inhibitor

Primary Target: thrombin
169756
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      Overview

      Replacement Information

      Key Spec Table

      CAS #
      90170-80-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      169756-1MG
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          		 Glass bottle 1 mg
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          Description
          OverviewSingle-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
          Catalogue Number169756
          Brand Family Calbiochem®
          SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
          References
          ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
          Product Information
          CAS number90170-80-2
          Unit of DefinitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
          ATP CompetitiveN
          FormSolid
          FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
          ReversibleN
          Applications
          ApplicationAntithrombin III, Human Plasma, CAS 90170-80-2, is a single-chain glycoprotein that acts as a principal physiological inhibitor of thrombin.
          Biological Information
          Primary Targetthrombin
          Puritysingle band by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥5 units/mg protein
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          169756

          References

          Reference overview
          Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-April-2008 RFH
          SynonymsATIII, Heparin cofactor, Factor Xa inhibitor
          DescriptionSingle chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.
          FormSolid
          FormulationLyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number90170-80-2
          Puritysingle band by SDS-PAGE
          Specific activity≥5 units/mg protein
          Unit definitionOne unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2
          SolubilityH₂O. Please refer to label for lot-specific volume prior to lyophilization.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesTsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.