181205 Arachidonic Acid, Porcine Liver, Sodium Salt - CAS 6610-25-9 - Calbiochem

181205
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₃₁O₂ · Na6610-25-9
      Description
      OverviewPrecursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein α-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway.
      Catalogue Number181205
      Brand Family Calbiochem®
      Synonymscis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, Na, 20:4
      References
      ReferencesHallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
      Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
      Han, J.-W., et al. 1991. Science 252, 576.
      Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
      Neddleman, P., et al. 1986. Annu. Rev. Biochem. 55, 69.
      Product Information
      CAS number6610-25-9
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₂₀H₃₁O₂ · Na
      Chemical formulaC₂₀H₃₁O₂ · Na
      ReversibleN
      Applications
      Biological Information
      Primary TargetRas-GAP
      Purity≥99% by TLC and GC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJX3874000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 36-26

      Wear suitable protective clothing.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      181205

      References

      Reference overview
      Hallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
      Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
      Han, J.-W., et al. 1991. Science 252, 576.
      Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
      Neddleman, P., et al. 1986. Annu. Rev. Biochem. 55, 69.

      Brochure

      Title
      Nitric Oxide and Oxidative Stress Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      Synonymscis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid, Na, 20:4
      DescriptionA cis-polyunsaturated fatty acid found in the plasma membrane. Major component of membrane phospholipids. Following its release by cellular phospholipases, it is enzymatically converted to a variety of inflammatory and vasoactive metabolites, such as prostaglandins (via the cyclooxygenase pathway), leukotrienes (via the lipoxygenase pathway), and epoxides (via the cytochrome P450 pathway). Binds to G-protein α-subunits in a covalent, posttranslational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number6610-25-9
      RTECSJX3874000
      Chemical formulaC₂₀H₃₁O₂ · Na
      Purity≥99% by TLC and GC
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Harmful
      Merck USA index14, 765
      ReferencesHallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
      Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
      Han, J.-W., et al. 1991. Science 252, 576.
      Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
      Neddleman, P., et al. 1986. Annu. Rev. Biochem. 55, 69.