189404 Aurora Kinase Inhibitor II - CAS 331770-21-9 - Calbiochem

189404
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₃H₂₀N₄O₃331770-21-9
      Description
      OverviewA cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC50 = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.
      Catalogue Number189404
      Brand Family Calbiochem®
      Synonyms4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
      References
      ReferencesHeron, N.M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1320.
      Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem. 5, 807.
      Product Information
      CAS number331770-21-9
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₂₃H₂₀N₄O₃
      Chemical formulaC₂₃H₂₀N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAurora Kinase
      Primary Target IC<sub>50</sub>310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      189404

      References

      Reference overview
      Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1320.
      Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem. 5, 807.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2007 JSW
      Synonyms4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
      DescriptionA cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC50 = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331770-21-9
      Chemical formulaC₂₃H₂₀N₄O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHeron, N.M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1320.
      Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem. 5, 807.