Key Spec Table
|Key Applications||Format||Host||Detection Methods|
|Antibody Type||Monoclonal Antibody|
|Safety Information according to GHS|
|Product Usage Statements|
|Material Size||1 mL|
|Reference overview||Pub Med ID|
|Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity. |
S-M Wang,T-S Ho,H-C Lin,H-Y Lei,J-R Wang,C-C Liu
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 31 2012
Enterovirus 71 (EV71) infection commonly strike children under the age of 3 years, with an occasionally unfavorable outcome in children. This study was designed to explore the relationship between age and the severity of complications, which may associate with antibody-dependent enhancement (ADE) in EV71. All EV71-infected patients during the outbreak of 2008 were recruited. In total, 134 patients were enrolled and categorized into two age groups, 0-12 months (n = 18) and >12 months (n = 116). Pulmonary edema/hemorrhage more commonly occur in patients younger than 12 months. No difference in the occurrence of herpangina/hand-foot-and-mouth disease (HFMD), uncomplicated brainstem encephalitis (BE), or autonomic nervous system (ANS) dysregulation was noted between the two age groups. Patients with pulmonary edema/hemorrhage (11.9 ± 14.7 months) were younger than patients with herpangina/HFMD (35.8 ± 26.4 months) or ANS dysregulation (33.9 ± 20.9 months). Our findings are in agreement with the data regarding the outbreak in Taiwan, in which a decrease in age corresponded to an increase in disease severity with regard to central nervous system complications. A reduction of maternal antibodies to the subneutralizing level within 1 year of age may be associated with the ADE of the infection. This study could provide possible clinical significance with regard to ADE phenomena in young infants infected by EV71.
|High expression of vascular endothelial growth factor in EV71-infected patients does not originate from EV71-infected cells. |
Shu-Chen Huang,Giri Raghavaraju,Hsiao-Sheng Liu
Intervirology 53 2010
Enterovirus (EV) 71 is an important pathogen causing death in children under 5 years of age worldwide. However, the core pathogenesis remains elusive. We reveal that the protein expression level of vascular endothelial growth factor (VEGF) in EV71 patients was 2-fold higher than in normal controls. However, the origin of VEGF in EV71-infected patients remains unclear.
|Enterovirus 71 infection induces apoptosis in Vero cells. |
Yoke-Fun Chan, Sazaly Abubakar
The Malaysian journal of pathology 25 29-35 2003
The effects of Enterovirus 71 (HEV71) infection on African green monkey kidney cells (Vero) were investigated. It was found that the infected cells showed progressive cellular morphological changes characteristic in apoptotic cells within 10 hours post-infection. The number of apoptotic cells correlated significantly with the number of HEV71 antigen positive cells when cells were labeled using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) and stained for HEV71 antigen. Approximately 11, 26, 45 and 50% of the infected cells were apoptotic at 12, 24, 48 and 72 hours post-infection, respectively. Internucleosomal DNA fragmentation, characteristic in the late stage of apoptosis was noted beginning on day 2 post-infection. The DNA fragmentation, however, was absent in cells treated with the heat- and ultraviolet light-inactivated virus inocula. These results demonstrate the capacity of HEV71 to induce apoptosis in the infected cells. The induction, however, requires high level of HEV71 infectivity and the presence of live virus particles, suggesting the need for the presence of specific viral proteins for apoptosis to occur.
|LIGHT DIAGNOSTICS Enterovirus 71 Reagent, ~25 tests - Data Sheet|
|LIGHT DIAGNOSTICS Enterovirus 71 Reagent, ~25 tests|