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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
28 Maio 2012
carregando
| Nº de produto | Qt/Emb |
|---|---|
| 553400-500UG | 500 μg |
A cell-permeable, ATP-site binding, and irreversible antifungal macrocyclic lactone antibiotic that acts as a protein tyrosine kinase inhibitor. Inhibits p60v-src kinase activity (IC50 = 0.27 nM). Inhibits the expression of COX-2 (IC50 = 27 nM) without affecting COX-1 expression in LPS-stimulated macrophages. Disrupts K-Ras-activated signaling pathways by selectively depleting Raf kinase. Inhibits tyrosine phosphorylation of p53/56lyn in LPS-stimulated macrophages. Suppresses NIH/3T3 cell transformation by diverse oncogenes such as src, ras, and mos in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Also exhibits anti-angiogenic activity in vivo. Inhibits Wnt-5A expression in dermal papilla cells (IC50 = 190 nM).
| Informações sobre o produto | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | p60v-src kinase activity | ||
| Primary Target IC50 | 0.27 nM | ||
| Secondary target | COX-2 (IC50 = 27 nM) | ||
| Protect from Light | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥98% by HPLC | ||
| Fórmula Química | C18H17ClO6 | ||
| RTECS | RR1105000 | ||
| Número CAS | 12772-57-5 | ||
| Merck USA index | 14, 6253 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
| Informações de segurança | |||
|---|---|---|---|
| Frases S |
S: 26-36 |
||
| Frases R |
R: 20/21/22-36/37/38 |
||
