ZIC®-HILIC technology from Merck increases food safety
New FDA method for detecting melamine and cyanuric acid in infant formula uses Merck SeQuant™ ZIC®-HILIC chromatography column
The contamination of food with melamine can cause severe illness – especially to children. Therefore, a reliable method is needed to determine melamine residues and related potential contaminations in food and particularly in milk products for children. Merck SeQuant™ ZIC®-HILIC technology offers a solution.
Reliable and sensitive: FDA recommends SeQuantTM ZIC®-HILIC from Merck
Recently, the U.S. Food and Drug Administration (FDA) announced that it has developed a method for simultaneously detecting residues of melamine and cyanuric acid in infant formula using the chromatography column SeQuantTM ZIC®-HILIC from Merck. The FDA regulates, among other things, the safety of foods in the U.S. Recommendations of the FDA receive global attention and are often adopted by national authorities in other countries.
The proposed method is a variant of liquid chromatography (hydrophilic liquid chromatography, HILIC) combined with mass spectrometry (LC-MS). With the use of SeQuantTM ZIC®-HILIC, even minute quantities of melamine and cyanuric acid can be precisely separated and detected. The limits of quantification and confirmation are 0.25 µg/g for both analytes. Thus, using SeQuantTM ZIC®-HILIC from Merck, the quality of infant formula can be reliably tested.
Simultaneous detection of melamine and cyanuric
The ZIC®-HILIC method proposed by the FDA offers a decisive advantage over alternative measurement methods: Infant formula contaminated with melamine may also contain other toxic triazine compounds such as cyanuric acid, which in combination with melamine can intensify the negative effects of the contaminated food. By simultaneously determining and confirming melamine and cyanuric acid in powdered milk-based infant formula, the proposed procedure considerably increases food safety.
More about the FDA method for detecting melamine and other substances in infant formula can be found at http://www.cfsan.fda.gov/~frf/lib4421.html.
| Products for the Determination of Melamine and Cyanuric Acid Residues in Infant Formula using LC-MS/MS: |
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HPLC column Standards and Reagents |
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