Resins for Fmoc SPPS of peptide amides
Resins supplied by Novabiochem® for the synthesis of peptide amides are functionalized with either the acid-labile modified Rink amide linker (Rink AM resin, Rink MBHA resin, and NovaSyn® TGR) or an equivalent handle directly linked to a polystyrene base matrix (Rink amide resin). Because attachment of the peptide is made via an amide bond, coupling of the first amino acid can be achieved using normal methods of amide bond formation. Since DMAP is not required for this step, there is no risk of enantiomerization or dipeptide formation. Detachment of peptide amides from these supports can be effected in a single step by treatment with 95% TFA.