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24 May 2013
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A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K+ conductivity in cell membranes at concentrations as low as 10-8 M. Often used in membrane electrode systems for determining K+ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
| Alternatives | |
|---|---|
| 368020 | Gramicidin A, High Purity, Bacillus brevis |
| Alternative products for Valinomycin, Streptomyces fulvissimus | |
| 368020 | Gramicidin A, High Purity, Bacillus brevis |
| Accessories for Valinomycin, Streptomyces fulvissimus |
| Product information | |||
|---|---|---|---|
| Form | White crystalline solid | ||
| Primary Target | NGF-induced neuronal differentiation | ||
| Molar mass | 1111.3 | ||
| Purity | ≥93% by HPLC | ||
| Specificity | Ion specificity: Rb+ > K+ > Cs+ > Ag+ > NH4+ > Na+ > Li+. | ||
| Solubility | Acetic Acid, Chloroform, DMSO, or Ether | ||
| Chemical formula | C54H90N6O18 | ||
| RTECS | YV9468000 | ||
| CAS number | 2001-95-8 | ||
| Merck USA index | 14, 9910 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic |
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| Safety information | |||
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| S Phrase |
S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed. |
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