Resins for Fmoc SPPS of peptide acids
Resins supplied by Novabiochem® for the synthesis of peptide acids are functionalized with either the acid labile hydroxymethylphenoxyacetic acid linker (NovaSyn® TGA) or an equivalent hydroxymethylphenoxymethyl handle directly linked to a polystyrene base matrix (Wang resin). Attachment of the first residue to these supports can be achieved either by DMAP catalyzed esterification with the appropriate symmetrical anhydride, by the 2,6-dichlorobenzoyl chloride technique of Sieber, or by using MSNT/MeIm activation. Detachment of the peptide with concurrent side-chain deprotection can be effected by treatment with 95% TFA.
