658401
AG 490
α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor VIII
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Merck Chemicals Ltd.
Padge Road, Beeston
NG9 2JR Nottingham
United Kingdom
Telefon: +44 (0)115 9430840
Fax: +44 (0)115 9430951
E-Mail: customer.service@merckbio.eu
20 Juni 2013
wird geladen
A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658411) in DMSO is also available.
| Produktinformationen | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | epidermal growth factor receptor kinase autophosphorylation | ||
| Primary Target IC50 | 100 nM | ||
| Secondary target | autokinase activity of JAK3, JAK2, constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells | ||
| Molare Masse | 294.3 | ||
| Protect from Light | Ja | ||
| Purity | ≥98% by HPLC | ||
| Löslichkeit in Wasser | DMSO | ||
| Chemische Formel | C17H14N2O3 | ||
| CAS-Nummer | 133550-30-8 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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