Wenn Sie allgemeine Fragen haben, wenden Sie sich bitte an unseren Kundenservice:
Merck Chemicals Ltd.
Padge Road, Beeston
NG9 2JR Nottingham
United Kingdom
Telefon: +44 (0)115 9430840
Fax: +44 (0)115 9430951
E-Mail: customer.service@merckbio.eu
19 Juni 2013
wird geladen
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
| Produktinformationen | |||
|---|---|---|---|
| Form | Solid | ||
| Primary Target | Akt1,Akt 2, Akt3 | ||
| Molare Masse | 320.3 | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Cell permeable | Ja | ||
| Purity | ≥95% by HPLC | ||
| Löslichkeit in Wasser | DMSO | ||
| Chemische Formel | C13H16N6O4 | ||
| RTECS | RY8455000 | ||
| CAS-Nummer | 35943-35-2 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |
||
