324841
EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor
1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828
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Merck Chemicals Ltd.
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NG9 2JR Nottingham
United Kingdom
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20 Juni 2013
wird geladen
A cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
| Produktinformationen | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Molare Masse | 405.3 | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥ 97% by HPLC | ||
| Löslichkeit in Wasser | DMSO or EtOH | ||
| Chemische Formel | C18H18Cl2N6O | ||
| CAS-Nummer | 1135256-66-4 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-24/25-37-45 |
||
