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Merck Chemicals Ltd.
Padge Road, Beeston
NG9 2JR Nottingham
United Kingdom
Telefon: +44 (0)115 9430840
Fax: +44 (0)115 9430951
E-Mail: customer.service@merckbio.eu
19 Juni 2013
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A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
| Produktinformationen | |||
|---|---|---|---|
| Form | Solid | ||
| Molare Masse | 581.5 | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥98% by TLC and HPLC | ||
| Löslichkeit in Wasser | DMSO or EtOH | ||
| Chemische Formel | C30H30Cl2N4O4 | ||
| CAS-Nummer | 548472-68-0 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Harmful |
||
