481411
NF-κB Activation Inhibitor III
3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
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25 Mai 2013
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A cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
| Produktinformationen | |||
|---|---|---|---|
| Form | Light yellow amorphous solid | ||
| Molare Masse | 328.7 | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥98% by HPLC | ||
| Löslichkeit in Wasser | DMSO | ||
| Chemische Formel | C10H5ClN4O5S | ||
| CAS-Nummer | 380623-76-7 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
