647925
Trichostatin A, Streptomyces sp.
4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA
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Merck Chemicals Ltd.
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22 Mai 2013
wird geladen
A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
| Produktinformationen | |||
|---|---|---|---|
| Form | Off-white lyophilized solid | ||
| Primary Target | histone deactylase | ||
| Secondary target | IL-2 gene expression (IC50 = 73 nM) | ||
| Molare Masse | 302.4 | ||
| Cell permeable | Ja | ||
| Reversible | Ja | ||
| Purity | ≥98% by HPLC | ||
| Löslichkeit in Wasser | DMSO, EtOH, MeOH | ||
| Chemische Formel | C17H22N2O3 | ||
| RTECS | MI5215000 | ||
| CAS-Nummer | 58880-19-6 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 26-36 |
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| R-Satz |
R: 20/21/22-36/37/38-43 |
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