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Merck Chemicals Ltd.
Padge Road, Beeston
NG9 2JR Nottingham
United Kingdom
Telefon: +44 (0)115 9430840
Fax: +44 (0)115 9430951
E-Mail: customer.service@merckbio.eu
23 Mai 2013
wird geladen
A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Shown to block doxazosin-induced osteoblastic differentiation. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Noncompetitive with respect to ATP. Also available in InSolution™ format (Cat. No. 662009).
| Produktinformationen | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | MEK1 | ||
| Primary Target IC50 | 72 nM | ||
| Secondary target | MEK2 (IC50 = 58 nM) | ||
| Molare Masse | 403.5 | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥98% by HPLC | ||
| Löslichkeit in Wasser | DMSO | ||
| Chemische Formel | C18H16N6S2•½C2H5OH | ||
| CAS-Nummer | 109511-58-2 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
