371715
Gliotoxin, Gladiocladium fimbriatum
2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a,10a-epidithio-pyrazinol[1,2α]indole-1,4-dione
Untuk pertanyaan umum, silakan hubungi Layanan Pelanggan kami:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Faks: +49 6151 72 2000
31 May 2012
memuat
An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes. Farnesyltransferase (FTase) inhibitor (IC50 = 1.1 µM). Reported to increase ryanodine Ca2+ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor. Specifically inhibits NF-κB activation in B and T cells at nanomolar concentrations.
| Informasi produk | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | FTase | ||
| Primary Target IC50 | 1.1 µM | ||
| Purity | ≥98% by TLC | ||
| Formulasi kimia | C13H14N2O4S2 | ||
| RTECS | KB4725000 | ||
| Nomor CAS | 67-99-2 | ||
| Merck USA index | 14, 4441 | ||
| Simpan dan kirim informasi | |||
|---|---|---|---|
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| Penyimpanan | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Informasi keselamatan kerja | |||
|---|---|---|---|
| Frase S |
S: 36/37/39-45 |
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| Frase R |
R: 23/24/25 |
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