For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recently shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting Na+ - Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phospholipase C inhibitor. Also inhibits phosphatidylcholine-phospholipase D activity (IC50 = 65 µM). Inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | angiogenin-induced angiogenesis | ||
| Primary Target Ki | phosphatidylcholine-phospholipase D activity (IC50 = 65 µM), inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg) | ||
| Molar mass | 908.9 | ||
| Protect from Light | Yes | ||
| Protect from Moisture | Yes | ||
| Activity | ≥600 IU/mg | ||
| Solubility | H2O | ||
| Chemical formula | C23H46N6O13 . 3H2SO4 | ||
| RTECS | QP4375000 | ||
| CAS number | 1405-10-3 | ||
| Merck USA index | 14, 6454 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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| Statement antibiotic | To purchase this product, the completion of a "Statement of Antibiotic Compliance" is required. Once your sales order is placed, our Regulatory Specialist will be contacting the end-user of this product to complete this statement. Please ensure to provide the customer service representative with the end-user's name, telephone number, fax number and e-mail address to prevent delivery delays. (Note: the completed statement must be returned within 5 business days from receipt and will be valid for one year.) | ||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-36/37-45 Do not breathe dust. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
||
| R Phrase |
R: 42/43-60-61 May cause sensitization by inhalation and skin contact. May impair fertility. May cause harm to the unborn child. |
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