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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Faks: +49 6151 72 2000
31 May 2012
memuat
A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
| Informasi produk | |||
|---|---|---|---|
| Form | Light yellow powder | ||
| Primary Target | (NO)-sensitive guanylyl cyclase | ||
| Primary Target IC50 | 20 nM | ||
| Protect from Light | Ya | ||
| Cell permeable | Ya | ||
| Purity | ≥98% by TLC and HPLC | ||
| Formulasi kimia | C9H5N3O2 | ||
| Nomor CAS | 41443-28-1 | ||
| Simpan dan kirim informasi | |||
|---|---|---|---|
| Penyimpanan | -20°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
| Informasi keselamatan kerja | |||
|---|---|---|---|
| Frase S |
S: 26-36 |
||
| Frase R |
R: 36/37/38 |
||
