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メルク株式会社
目黒区下目黒1-8-1
153-8927 東京
Japan
TEL： 0120-189-390
Fax: 0120-189-350
E-mail mj_service@merckgroup.com
31 5月 2012
ローディング
Leflunomide metabolite that blocks TNF-dependent NF-κB activation and gene expression. Inhibits the activity of dihydroorotate dehydrogenase (DHO-DH; IC50 = 220 nM). Reported to reduce IFN-γ-induced expression of iNOS in L929 fibroblasts. Inhibits IL-1β-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells. A cell-permeable, reversible, and substrate competitive inhibitor that inhibits the IL-2-induced tyrosine phosphorylation of JAK1 and JAK3.
| 製品情報 | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | DHO-DH | ||
| Primary Target IC50 | 220 nM | ||
| Secondary target | IL-1b-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells | ||
| Protect from Light | はい | ||
| Packaged under inert gas | はい | ||
| Purity | ≥97% by HPLC | ||
| 化学式 | C12H9F3N2O2 | ||
| CAS 番号 | 108605-62-5 | ||
| 保管と送付情報 | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
| 安全性情報 | |||
|---|---|---|---|
| S フレーズ |
S: 22-36 |
||
| R フレーズ |
R: 40 |
||
