227013
CCR4 Antagonist
2-(1,4′-Bipiperidine-1′-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
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メルク株式会社
目黒区下目黒1-8-1
153-8927 東京
Japan
TEL： 0120-189-390
Fax: 0120-189-350
E-mail mj_service@merckgroup.com
31 5月 2012
ローディング
A cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
| 製品情報 | |||
|---|---|---|---|
| Form | Light beige solid | ||
| Protect from Light | はい | ||
| Packaged under inert gas | はい | ||
| Purity | ≥97% by HPLC | ||
| 化学式 | C27H41N5O2 • 0.5 H2O | ||
| CAS 番号 | 864289-85-0 | ||
| 保管と送付情報 | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
