234200
Combretastatin A-4
NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII
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メルク株式会社
目黒区下目黒1-8-1
153-8927 東京
Japan
TEL： 0120-189-390
Fax: 0120-189-350
E-mail mj_service@merckgroup.com
31 5月 2012
ローディング
A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
| 製品情報 | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Protect from Light | はい | ||
| Packaged under inert gas | はい | ||
| Purity | ≥97% by HPLC | ||
| 化学式 | C18H20O5 | ||
| CAS 番号 | 117048-59-6 | ||
| 保管と送付情報 | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
| 安全性情報 | |||
|---|---|---|---|
| S フレーズ |
S: 22-24/25-36 |
||
