346006
Glucagon-Like Peptide 1 Receptor Agonist
6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline, GLP-1R Agonist
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メルク株式会社
目黒区下目黒1-8-1
153-8927 東京
Japan
TEL： 0120-189-390
Fax: 0120-189-350
E-mail mj_service@merckgroup.com
31 5月 2012
ローディング
A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
| 製品情報 | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Protect from Light | はい | ||
| Packaged under inert gas | はい | ||
| Purity | ≥97% by HPLC | ||
| 化学式 | C13H15Cl2N3O2S | ||
| CAS 番号 | 281209-71-0 | ||
| 保管と送付情報 | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Regulatory Review |
||
