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Merck KGaA
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31 May 2012
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A cell-permeable rotenoid compound that displays anti-proliferative properties. Potently inhibits mitochondrial bioenergetics (IC50 = 6.9 nM for NADH:ubiquinone oxidoreductase activity in bovine heart ETP) and promotes mitochondrial permeability transition. Blocks phorbol ester-induced ornithine decarboxylase activity in MCF-7 cells (IC50 = 11 nM) and induces apoptosis and cell cycle arrest. Selectively blocks Akt activation with minimal effects on MAPK signaling. Also shown to activate AMPK activity and inhibit COX2 expression.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | mitochondrial bioenergetics NADH | ||
| Primary Target IC50 | 6.9 nM for NADH:ubiquinone oxidoreductase activity in bovine heart ETP | ||
| Secondary target | Blocks phorbol ester-induced ornithine decarboxylase activity in MCF-7 cells (IC50 = 11 nM) and induces apoptosis and cell cycle arrest | ||
| Molar mass | 394.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C23H22O6 | ||
| RTECS | DX1500000 | ||
| CAS number | 522-17-8 | ||
| Merck USA index | 14, 2863 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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