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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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This product has been discontinued.
We apologize for the inconvenience, but we do not currently have an alternative product. For related products please refer to our complete listing of nucleotides, nucleosides, purines, and pyrmidines. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A cell-permeable, potent, selective, ATP-competitive and irreversible inhibitor of the catalytic domain of the ErbB subfamily of protein tyrosine kinases. Inactivates ErbB1 (epidermal growth factor receptor) modifying the cysteine residue Cys797 at the active site. This inactivation is reversed with the addition of 1 mM DTT. Also inhibits ErbB2 (Neu/Her2 growth factor receptor; IC50 = 45 µM). This product is very unstable when exposed to oxygen. Unstable in solution; reconstitute just prior to use.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | ErbB2 Neu/Her2 growth factor receptor | ||
| Primary Target IC50 | IC50 = 45 µM | ||
| Molar mass | 283.3 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C10H13N5O3S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
||
