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31 May 2012
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A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
| Alternatives | |
|---|---|
| 100107 | A23187, 4-Bromo- |
| 100106 | A23187, Mixed Calcium-Magnesium Salt |
| Alternative products for A23187, Free Acid, Streptomyces chartreusensis | |
| 100107 | A23187, 4-Bromo- |
| 100106 | A23187, Mixed Calcium-Magnesium Salt |
| Accessories for A23187, Free Acid, Streptomyces chartreusensis |
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Molar mass | 523.6 | ||
| Protect from Light | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C29H37N3O6 | ||
| RTECS | DM4676000 | ||
| CAS number | 52665-69-7 | ||
| Merck USA index | 14, 1639 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36/37/39 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. |
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| R Phrase |
R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
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