110123
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata
AKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
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Fax: +49 6151 72 2000
31 May 2012
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A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | 5-lipoxygenase | ||
| Primary Target IC50 | 1.5 µM in rat PMNLs | ||
| Molar mass | 512.7 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C32H48O5 | ||
| CAS number | 67416-61-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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