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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Teléfono: +49 6151 72-0
Fax: +49 6151 72 2000
31 mayo 2012
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Anti-neoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. At higher concentrations, DNA polymerase is inhibited. Also acts as a competitive inhibitor of serine proteases. Inhibits cell growth and colony formation in synchronized HeLa cells. Induces apoptosis in many cell lines. However, actinomycin D has also been shown to suppress etoposide-induced apoptosis in PC12 cells. Note: 1 set = 20 x 200 µg.
Stability: heat resistant and stable between pH 2 and 11. Decomposed by strong acids and bases.
| Información sobre producto | |||
|---|---|---|---|
| Form | Red crystalline solid | ||
| Primary Target | serine proteases | ||
| Secondary target | cell growth and colony formation in synchronized HeLa cells | ||
| Protect from Light | Si | ||
| Hygrocopic | Si | ||
| Purity | ≥98% by HPLC | ||
| Fórmula químico | C62H86N12O16 | ||
| RTECS | AU1575000 | ||
| Número CAS | 50-76-0 | ||
| Merck USA index | 14, 2800 | ||
| Almacenar y enviar información | |||
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Advertencia de materiales peligrosos: Debido a la naturaleza de los materiales peligrosos de este envío, podrían aplicarse gastos de envío añadidos a su pedido. Ciertos tamaños pueden estar exentos de los gastos de envío añadidos a los materiales peligrosos. Consulte a su oficina local de ventas si desea más información relativa a esos gastos. |
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| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 28-36/37-45 |
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| Frase R |
R: 28 |
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