116850
Adenylyl Cyclase Type V Inhibitor, NKY80
2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
24 May 2012
loading
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
| Product information | |||
|---|---|---|---|
| Form | Pale orange solid | ||
| Primary Target | (AC) type V isoform | ||
| Primary Target IC50 | 8.3 µM | ||
| Secondary target | (IC50 = 132 µM and 1.7 mM for type III and II, respectively) in the presence of Gsa GTPgS-Forskolin | ||
| Molar mass | 229.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C12H11N3O2 | ||
| CAS number | 299442-43-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
||
