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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A potent hypotensive peptide hormone with structural similarity to calcitonin gene-related peptide. Inhibits 125I-adrenomedullin binding to specific sites in brain (IC50 = 1.2 nM). Has vasodilatory properties. Suppresses CRF-induced ACTH-release from cultured primary cells. Reported to augment nitric oxide synthase expression in IL-1β -stimulated cardiac myocytes.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 | ||
| Form | Lyophilized | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 6028.8 | ||
| Hygrocopic | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C264H406N80O77S3 | ||
| CAS number | 148498-78-6 | ||
| Declaration | Sold under license of U.S. Patent 5,910,416 and corresponding patents. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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