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24 May 2013
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A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Inhibits neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines.
| Product information | |||
|---|---|---|---|
| Form | Dark yellow solid | ||
| Primary Target | epidermal growth factor receptor tyrosine kinase | ||
| Primary Target IC50 | 3 µM | ||
| Secondary target | GTPase activity of transducin (IC50 = 7 µM), neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase) | ||
| Molar mass | 202.2 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C10H6N2O3 | ||
| CAS number | 118409-58-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
