565767
α-Secretase Substrate II, Fluorogenic
Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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An internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP). Shown to be a substrate for yapsin 2, a glycosyl-phosphatidylinositol-linked yeast aspartyl protease (Vmax/Km = 0.031 min-1). The cleavage is shown to occur at the Lys-Leu bond.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH | ||
| Form | Red solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 2118.5 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Excitation max. | ~340 nm | ||
| Emission max. | ~490 nm | ||
| Solubility | DMSO | ||
| Chemical formula | C100H144N30O20S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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