Alzheimer's Disease Related Products - a-Secretase

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Alzheimer's Home Alzheimer's Interactive Pathway™ Alzheimer's Brain Tissue Sections a-Secretase b-Amyloid b-Secretase g-Secretase Tau GSK-3 Acetylcholinesterase Cyclooxygenase

APP can also be processed by a-secretase, which cleaves within the Ab domain between Lys⁶⁸⁷ and Leu⁶⁸⁸ and produces a large soluble a-APP domain and the C-terminal fragment containing P3 and C83. The latter can then be cleaved by g-secretase at residue 711 or 713 to release P3 fragment. This pathway does not yield Ab peptide. Hence, shunting APP towards the a-secretase pathway may have a beneficial effect in lowering Ab peptide levels. It is reported that a-secretase shares many of its properties with the secretase that cleaves angiotensin-converting enzyme and is believed to be a zinc metalloproteinase of the ADAMs family (variously ADAM9, ADAM10 and ADAM17/TACE have been implicated). Muscarinic agonists (M1 and M3) and some PKC activators are reported to enhance a-secretase activity and are under consideration for their therapeutic value as AD treatment tools.

a-Secretase Antibodies

	Cat. No.	Product
[+]	422751	Anti-ADAM10 (735-749) Rabbit pAb
[+]	PC528	Anti-ADAM10 (Ab-1) (732-748) Rabbit pAb
[+]	PC669	Anti-ADAM9 Goat pAb
[+]	PC491	Anti-TACE (807 - 823) Rabbit pAb

a-Secretase Kits

a-Secretase Modulator

	Cat. No.	Product
[+]	565740	α-Amyloid Precursor Protein Modulator

a-Secretase Proteins

	Cat. No.	Product
[+]	565740	α-Amyloid Precursor Protein Modulator

a-Secretase Substrates

	Cat. No.	Product
[+]	444282	MMP/TACE Substrate, FS-6
[+]	565751	α-Secretase Substrate I, Fluorogenic
[+]	565767	α-Secretase Substrate II, Fluorogenic
[+]	616402	TACE Substrate II, Fluorogenic
[+]	616403	TACE Substrate III, Fluorogenic
[+]	616407	TACE Substrate IV, Fluorogenic

Functional Class : ADAM10 endopeptidase

Name	ADAM10 endopeptidase
Description	myelin-associated disintegrin metalloproteinase
URN	urn:agi-enz:3.4.24.81
Total Controls	0
Total Nodes	0
Total Members	0
Notes	In peptidase family M12. Partially responsible for the "alpha-secretase" activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.
Connectivity	0

Alias	ADAM10 endopeptidase
	Kuzbanian protein
	myelin-associated disintegrin metalloproteinase
	alpha-secretase

EC Number	3.4.24.81

Class	Hydrolases
	Acting on peptide bonds (peptidases)
	Metalloendopeptidases

Reference	Gutwein, P., Mechtersheimer, S., Riedle, S., Stoeck, A., Gast, D., Joumaa, S., Zentgraf, H., Fogel, M. and Altevogt, D.P. ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J. 17 (2003) 292-294.

DB Link	IUBMB Enzyme Nomenclature: 3.4.24.81
	ExPASy - ENZYME nomenclature database: 3.4.24.81
	ERGO genome analysis and discovery system: 3.4.24.81
	BRENDA, the Enzyme Database: 3.4.24.81

Source	KEGG