Alzheimer's Disease Related Products - b-Secretase
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Alzheimer's disease (AD) is characterized by a progressive deposition of the 4 kDa b-amyloid peptide (Ab) in senile plaques and accumulation of tau protein as neurofibrillary tangles. In normal healthy individuals, Ab peptides are present only in small quantities as soluble monomers that circulate in cerebrospinal fluid and blood. However, in AD patients, their levels are significantly increased and they begin to accumulate as insoluble, fibrillar plaques. Ab is a 40 to 43 amino acid peptide that originates from the proteolytic cleavage of the amyloid precursor protein (APP). Processing of APP in vivo occurs by two major pathways. Cleavage of APP at the N-terminus of the Ab region by b-secretase and at the C-terminus by g-secretases represents the amyloidogenic pathway for processing of APP. The b-secretase cleaves APP between residues Met671 and Asp672 and yields sAAPb and C99 fragments. The b-secretase has also been identified as an aspartyl protease (BACE or Asp-2) of unusual nature. It has a C-terminal transmembrane domain and two active site motifs located in the luminal domain.
APP can also be processed by a-secretase (TACE), which cleaves within the Ab domain between Lys687 and Leu688 and produces a large soluble a-APP domain and the C-terminal fragment containing P3 and C83.. The latter can then be cleaved by g-secretase at residue 711 or 713 to release P3 fragment. This pathway does not yield Ab peptide. Hence, shunting APP towards the a-secretase pathway may have a beneficial effect in lowering Ab peptide levels.
b-Secretase Antibodies
b-Secretase Inhibitors
b-Secretase Proteins
| Cat. No. | Product | |
|---|---|---|
| [+] | PF125 | BACE1, His•Tag®, Human, Recombinant, NSO Cells |
b-Secretase Substrates
b-Secretase Assay Kit
| Cat. No. | Product | |
|---|---|---|
| [+] | 565785 | β-Secretase Activity Assay Kit, Fluorogenic |
| BACE1 | |
|---|---|
| Protein : BACE1 | 90 |
| Connectivity | 90 |
| Notes | Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. |
| Hugo ID | 933 |
| Name | BACE1 |
| Description | beta-site APP-cleaving enzyme 1 |
| URN | urn:agi-llid:23621 |
| GO Cellular Component | integral to membrane extracellular space Golgi apparatus endosome integral to plasma membrane |
| Cell Localization | Plasma membrane Cytoplasm Golgi |
| GO Biological Process | proteolysis and peptidolysis beta-amyloid metabolism membrane protein ectodomain proteolysis |
| EC Number | 3.4.23.46 |
| State | isoform a preproprotein isoform c preproprotein isoform b preproprotein isoform D preproprotein |
| State Description | Transcript Variant: This variant (a) is the longest transcript and it encodes the longest isoform (A). Transcript Variant: This variant (c) uses a different splice site in the coding region exon, compared to transcript variant a. The resulting isoform (C) lacks an internal segment when compared to isoform A. Transcript Variant: This variant (b) uses a different splice site in the coding region when compared to transcript variant a. The resulting isoform (B) lacks an internal segment when compared to isoform A. Transcript Variant: This variant (d) uses different splice sites in two coding region exons, compared to transcript variant a. The resulting isoform (D) lacks an internal segment when compared to isoform A. |
| MGI ID | 1346542 |
| Swiss-Prot Accession | P56817 |
| OMIM ID | OMIM:604252 |
| Alias | Bace beta-site APP cleaving enzyme Bace1 beta-site APP cleaving enzyme 1 APP beta-secretase HSPC104 beta-site APP-cleaving enzyme 1 memapsin-2 beta-secretase aspartyl protease 2 transmembrane aspartic proteinase Asp2 membrane-associated aspartic protease 2 beta-site amyloid precursor protein cleaving enzyme beta-site amyloid beta A4 precursor protein-cleaving enzyme KIAA1149 ASP2 Aspartyl protease 2 Aspartyl protease II BACE I Beta-secretase precursor beta-site APP cleaving enzyme I Memapsin II Membrane-associated aspartic protease II transmembrane asparticase Asp2 |
| Organism | Rattus norvegicus Mus musculus Human |
| Entrez Gene links | 29392 23821 97509 23621 |
| RGD ID | 2191 |
| Pathway | Alzheimers |
| Unigene ID | Rn.48895 Mm.24044 Hs.49349 |
