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Alzheimer's Disease Related Products - Cyclooxygenase (COX)

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For over 30 years, non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit the activity of cyclooxygenase (COX-1 and COX-2) have been the primary drugs used in the treatment of various rheumatological disorders, inflammation, and chronic pain. More recently, there has been an upsurge of interest in COX-2 inhibitors as possible candidates for the treatment of Alzheimer’s disease (AD). This is due to the fact that researchers have begun to think about “inflammation as a factor” in the development and/or progression of Alzheimer’s disease.

Most researchers believe that inflammation contributes to the neuronal damage and that reducing inflammation may help slow or prevent the progression of AD. Several epidemiological studies have shown that groups of people who are on NSAIDs for such conditions as rheumatoid arthritis have a reduced probability of developing AD. It is reported that NSAIDs inhibit human Ab aggregation in vitro and reverse the b-sheet conformation of preformed fibrils.

 

Cyclooxygenase Inhibitors

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  Cat. No. Product
[+] 484100 5-Nitro-2-(3-phenylpropylamino)benzoic Acid
[+] 236005 COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
[+] 236011 COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem
[+] 236012 COX-2 Inhibitor II - CAS 181696-33-3 - Calbiochem
[+] 236013 COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem
[+] 236014 COX-2 Inhibitor IV
[+] 236015 COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem
[+] 239802 Curcumin, Curcuma longa L. - CAS 458-37-7 - Calbiochem
[+] 239783 Cyclooxygenase Inhibitor Set - Calbiochem
[+] 287845 Diclofenac, 4′-Hydroxy-
[+] 287840 Diclofenac Sodium - CAS 15307-79-6 - Calbiochem
[+] 317500 DuP-697
[+] 324483 Ebselen - CAS 60940-34-3 - Calbiochem
[+] 434741 ETYA
[+] 344079 Flurbiprofen - CAS 5104-49-4 - Calbiochem
[+] 405268 Indomethacin - CAS 53-86-1 - Calbiochem
[+] 405271 Indomethacin Ester, 4-Methoxyphenyl-
[+] 420345 Kaempferol - CAS 520-18-3 - Calbiochem
[+] 444800 Meloxicam
[+] 481987 Niflumic Acid
[+] 349254 NS-398 - CAS 123653-11-2 - Calbiochem
[+] 401003 (±)-Ibuprofen - CAS 15687-27-1 - Calbiochem
[+] 523310 Pterostilbene, Pterocarpus marsupium
[+] 553400 Radicicol, Diheterospora chlamydosporia
[+] 554325 Resveratrol
[+] 565610 SC-560
[+] 567305 SKF-86002
[+] 567630 Sodium Salicylate
[+] 574102 Sulindac Sulfide
[+] 574105 Sulindac Sulfone

© Merck KGaA, Darmstadt, Germany, 2014


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