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Merck KGaA
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64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
24 May 2012
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Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH | ||
| Form | White to off-white solid | ||
| Primary Target | adenylate cyclase activity | ||
| Molar mass | 1046.2 | ||
| Hygrocopic | Yes | ||
| Purity | ≥98% by HPLC | ||
| Sold on the basis of peptide content | Yes | ||
| Solubility | H2O or 5% Acetic Acid | ||
| Chemical formula | C50H71N13O12 | ||
| RTECS | BW2165000 | ||
| CAS number | 4474-91-3 | ||
| Merck USA index | 14 651 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
