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178005  Anthopleurin A

AP-A, Anthopleura Toxin A, Toxin A

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Merck KGaA
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01 June 2012

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Synthetic. Sequence from toxin isolated from the sea anemone Anthopleura xanthogrammica. Inhibits the inactivation of voltage-gated Na+ channels. Prolongs ventricular repolarization. Has inotropic but no chronotropic effects on mammalian heart preparations.
Product information
Peptide Sequence H-Gly-Val-Ser-Cys4-Leu-Cys6-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Thr-Leu-Trp-Leu-Tyr-Pro-Ser-Gly-Cys29-Pro-Ser-Gly-Trp-His-Asn-Cys36-Lys-Ala-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys46-Cys47-Lys-Gln-OH (disulfide bonds: 4 → 46; 6 → 36; 29 → 47)
Form Lyophilized
Molar mass 5131.8
Hygrocopic Yes
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C220H326N64O67S6
Store and ship information

Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Storage +2°C to +8°C
Ship Ambient Temperature Only
Toxic
Safety information
S Phrase S: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase R: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.

© Merck KGaA, Darmstadt, Germany, 2012


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