189422
Australine, Hydrochloride, Castanospermum australe
(1R,2R,3R,7S,7aR)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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This product has been discontinued.
Please refer to our complete listing of protease glycoprotein processing and trafficking inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A polyhydroxylated pyrrolizidine alkaloid that inhibits α-glucosidase, amyloglucosidase, and glucosidase I. Appears to be the first glucosidase inhibitor that is active toward glucosidase I but not glucosidase II. Inhibits glycoprotein processing at the glucosidase I step, resulting in the accumulation of glycoproteins containing Glc3Man7-9(GlcNAc)2-oligosaccharides. Does not inhibit α- or β-galactosidase, β-glucosidase, or α- or β-mannosidase.
| Product information | |||
|---|---|---|---|
| Form | Crystalline solid | ||
| Primary Target | glucosidase 1 | ||
| Molar mass | 225.7 | ||
| Hygrocopic | Yes | ||
| Purity | ≥95% by TLC | ||
| Solubility | EtOH, MeOH, or H2O | ||
| Chemical formula | C8H15NO4 · HCl | ||
| CAS number | 186766-07-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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